Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 17/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.39 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17837625 | 0.88 | AXL (0.53) | AXLMAP4K4MAP4K3 | |
| SCHEMBL17837584 | 0.83 | MAP4K3 (0.53) | AXLMAP4K4MAP4K3 | |
| SCHEMBL17844436 | 0.82 | AXL (0.56) | AXLMAP4K4 | |
| SCHEMBL17861735 | 0.80 | AXL (0.62) | AXLMAP4K4 | |
| SCHEMBL17837879 | 0.79 | AXL (0.56) | AXL | |
| SCHEMBL17837680 | 0.79 | AXL (0.64) | AXLMAP4K4 | |
| SCHEMBL17837942 | 0.77 | AXL (0.76) | AXL | |
| SCHEMBL17844439 | 0.76 | MAP4K4 (0.48) | AXLMAP4K4MAP4K3TRPC6 | |
| SCHEMBL17837402 | 0.73 | AXL (1.00) | AXL | |
| SCHEMBL17857699 | 0.72 | AXL (0.81) | AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233829-A1 | PYRIMIDINE AND TRIAZINE DERIVATIVES AND THEIR USE AS AXL INHIBITORS | Pfizer Inc (US) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016097918-A1 | PYRIMIDINE AND TRIAZINE DERIVATIVES AND THEIR USE AS AXL INHIBITORS | PFIZER INC. (US) | 2016-06-23 | — | — | WO | disclosed |