Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.30 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22652026 | 0.80 | MAPK9 (0.35) | MAPK9MAPK10 | |
| SCHEMBL22576353 | 0.78 | MAPK9 (0.36) | MAPK9MAPK10 | |
| SCHEMBL12845661 | 0.76 | KDM4C (0.38) | SIGMAR1 | |
| SCHEMBL558541 | 0.75 | MAPK9 (0.39) | MAPK9MAPK10 | |
| SCHEMBL4564037 | 0.74 | MAPK9 (0.34) | MAPK9MAPK10 | |
| SCHEMBL27523149 | 0.74 | MAPK9 (0.38) | MAPK9MAPK10 | |
| SCHEMBL24369084 | 0.72 | MAPK9 (0.33) | MAPK9MAPK10 | |
| SCHEMBL5671975 | 0.72 | KCNA5 (0.35) | MAPK9MAPK10 | |
| SCHEMBL22065924 | 0.72 | MAPK9 (0.37) | MAPK9MAPK10 | |
| SCHEMBL2018148 | 0.72 | MAPK9 (0.37) | MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016095205-A1 | HETEROARYL OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2016-06-23 | — | — | WO | disclosed |