Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 6/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | TLR2 | O60603 | 1/20 | 0.33 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | MDM4 | O15151 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17846100 | 0.87 | MAPK1 (0.42) | MAPK1RETMAPTS1PR3 | |
| SCHEMBL17846129 | 0.78 | MAPK1 (0.43) | MAPK1RETMAPTS1PR3 | |
| SCHEMBL17846204 | 0.78 | MAPK1 (0.39) | MAPK1RETMAPTS1PR3 | |
| SCHEMBL17846138 | 0.77 | MAPK1 (0.42) | MAPK1RETMAPTS1PR3 | |
| SCHEMBL17846206 | 0.77 | MAPK1 (0.42) | MAPK1RETMAPTS1PR3 | |
| SCHEMBL19350261 | 0.77 | MAPK1 (0.42) | MAPK1RETMAPT | |
| SCHEMBL17846145 | 0.76 | MAPK1 (0.43) | MAPK1 | |
| SCHEMBL17846195 | 0.75 | MAPK1 (0.51) | MAPK1 | |
| SCHEMBL17846220 | 0.73 | MAPT (0.40) | MAPK1RETMAPTS1PR3 | |
| SCHEMBL17846022 | 0.71 | MAPK1 (0.50) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233859-A1 | ERK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016100051-A1 | ERK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-06-23 | — | — | WO | disclosed |