Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20204239 | 1.00 | MAPK1 (0.45) | MAPK1HCAR2 | |
| SCHEMBL17846072 | 0.93 | MAPK1 (0.47) | MAPK1HCAR2 | |
| SCHEMBL19349001 | 0.89 | MAPK1 (0.43) | MAPK1 | |
| SCHEMBL19349003 | 0.89 | MAPK1 (0.43) | MAPK1 | |
| SCHEMBL17846172 | 0.84 | BCDIN3D (0.39) | MAPK1 | |
| SCHEMBL17846039 | 0.81 | MAPK1 (0.38) | MAPK1 | |
| SCHEMBL17846165 | 0.78 | MAPK1 (0.51) | MAPK1 | |
| SCHEMBL17846135 | 0.78 | MAPK1 (0.42) | MAPK1 | |
| SCHEMBL17846043 | 0.77 | MAPK1 (0.44) | MAPK1 | |
| SCHEMBL17846041 | 0.77 | MAPK1 (0.44) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233859-B1 | BRIDGED PYRAZOLOPYRIDINE DERIVATIVES AS ERK INHIBITORS USEFUL FOR THE TREATEMENT OF CANCER | MERCK SHARP & DOHME (US) | 2019-08-07 | — | — | EP | disclosed |
| US-9988397-B2 | ERK inhibitors | MERCK SHARP & DOHME CORP. (US) | 2018-06-05 | — | — | US | disclosed |
| EP-3233859-A1 | ERK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016100051-A1 | ERK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-06-23 | — | — | WO | disclosed |