Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 18/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.31 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17846110 | 0.82 | MAPK1 (0.45) | MAPK1 | |
| SCHEMBL19348976 | 0.82 | MAPK1 (0.42) | MAPK1 | |
| SCHEMBL17844851 | 0.82 | MAPK1 (0.42) | MAPK1 | |
| SCHEMBL17846041 | 0.81 | MAPK1 (0.44) | MAPK1 | |
| SCHEMBL17846043 | 0.81 | MAPK1 (0.44) | MAPK1 | |
| SCHEMBL17846016 | 0.81 | MAPK1 (0.39) | MAPK1 | |
| SCHEMBL17846048 | 0.76 | MAPK1 (0.45) | MAPK1 | |
| SCHEMBL21219030 | 0.76 | MAPK1 (0.43) | MAPK1 | |
| SCHEMBL19348964 | 0.75 | MAPK1 (0.41) | MAPK1 | |
| SCHEMBL17846113 | 0.75 | MAPK1 (0.44) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233859-A1 | ERK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016100051-A1 | ERK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-06-23 | — | — | WO | disclosed |