Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 20/20 | 0.81 |
| ▸ | CREBBP | Q92793 | 20/20 | 0.81 |
| ▸ | EP300 | Q09472 | 5/20 | 0.81 |
| ▸ | TAF1 | P21675 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17846751 | 1.00 | BRD4 (0.81) | BRD4CREBBPEP300TAF1 | |
| SCHEMBL17785802 | 0.90 | BRD4 (1.00) | BRD4CREBBPEP300TAF1 | |
| SCHEMBL17785803 | 0.90 | BRD4 (1.00) | BRD4CREBBPEP300TAF1 | |
| SCHEMBL17795442 | 0.90 | BRD4 (1.00) | BRD4CREBBPEP300TAF1 | |
| SCHEMBL17795118 | 0.81 | CREBBP (1.00) | BRD4CREBBPEP300TAF1 | |
| SCHEMBL17794818 | 0.80 | CREBBP (1.00) | BRD4CREBBPEP300 | |
| SCHEMBL17795190 | 0.80 | CREBBP (1.00) | BRD4CREBBPEP300TAF1 | |
| SCHEMBL17799427 | 0.80 | CREBBP (1.00) | BRD4CREBBPEP300TAF1 | |
| SCHEMBL17794719 | 0.79 | BRD4 (1.00) | BRD4CREBBPEP300 | |
| SCHEMBL17795090 | 0.79 | BRD4 (1.00) | BRD4CREBBPEP300TAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016086200-A9 | 4,5,6,7-TETRAHYDRO-1 H-PYRAZOLO[4,3-C]PYRIDIN-3-AMINE COMPOUNDS AS CBP AND/OR EP300 INHIBITORS | GENENTECH, INC. (US) | 2016-06-23 | — | — | WO | disclosed |