Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK3 | P27361 | 17/20 | 0.51 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.46 |
| ▸ | CDC7 | O00311 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
| ▸ | CDK7 | P50613 | 1/20 | 0.46 |
| ▸ | CDK9 | P50750 | 1/20 | 0.46 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ULK1 | O75385 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15937970 | 0.85 | MAPK3 (0.53) | MAPK3PTK2CDC7ROCK2MAP4K4 | |
| SCHEMBL15937914 | 0.83 | MAPK3 (0.72) | MAPK3MAPK1 | |
| SCHEMBL15948509 | 0.79 | MAPK3 (0.53) | MAPK3PTK2CDC7ROCK2MAP4K4 | |
| SCHEMBL1202633 | 0.77 | CDC7 (0.70) | CDC7ROCK2MAP4K4PIM1PRKACA | |
| SCHEMBL5563903 | 0.77 | CDC7 (0.55) | MAPK3PTK2CDC7ROCK2MAP4K4 | |
| SCHEMBL17847673 | 0.75 | MAPK3 (0.65) | MAPK3MAPK1 | |
| SCHEMBL2029526 | 0.75 | PTK2 (0.58) | MAPK3PTK2CDC7ROCK2MAP4K4 | |
| SCHEMBL31260501 | 0.75 | PTK2 (0.50) | MAPK3PTK2CDC7ROCK2MAP4K4 | |
| SCHEMBL29832770 | 0.74 | PTK2 (0.52) | MAPK3PTK2ULK1 | |
| SCHEMBL21847031 | 0.74 | PTK2 (0.52) | MAPK3PTK2ULK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016100452-A2 | HETEROARYL COMPOUNDS AND USES THEREOF | CELGENE AVILOMICS RESEARCH, INC. (US) | 2016-06-23 | — | — | WO | disclosed |