Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 20/20 | 0.41 |
| ▸ | FABP1 | P07148 | 2/20 | 0.38 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17856087 | 1.00 | NR1H4 (0.41) | NR1H4FABP1GPBAR1 | |
| SCHEMBL17839496 | 1.00 | NR1H4 (0.41) | NR1H4FABP1GPBAR1 | |
| SCHEMBL17856086 | 0.91 | NR1H4 (0.39) | NR1H4FABP1 | |
| SCHEMBL17839783 | 0.91 | NR1H4 (0.39) | NR1H4FABP1 | |
| SCHEMBL17839790 | 0.85 | TDP1 (0.46) | NR1H4 | |
| SCHEMBL17839792 | 0.85 | TDP1 (0.46) | NR1H4 | |
| SCHEMBL17856084 | 0.84 | NR1H4 (0.53) | NR1H4 | |
| SCHEMBL17839162 | 0.84 | NR1H4 (0.53) | NR1H4 | |
| SCHEMBL17839406 | 0.83 | NR1H4 (0.54) | NR1H4FABP1 | |
| SCHEMBL17848920 | 0.83 | NR1H4 (0.54) | NR1H4FABP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233850-A1 | HYDROXY CONTAINING FXR (NR1H4) MODULATING COMPOUNDS | Gilead Sciences, Inc. (US) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016096115-A1 | HYDROXY CONTAINING FXR (NR1H4) MODULATING COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2016-06-23 | — | — | WO | disclosed |