Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 14/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18588956 | 0.84 | NR1H2 (0.42) | NTRK1NR1H2NR1H3GPR119JAK2 | |
| SCHEMBL16293086 | 0.83 | NTRK1 (0.41) | NTRK1NR1H2NR1H3GPR119JAK2 | |
| SCHEMBL15017396 | 0.83 | NTRK1 (0.41) | NTRK1NR1H2NR1H3GPR119JAK2 | |
| SCHEMBL18878036 | 0.83 | NTRK1 (0.45) | NTRK1NR1H2NR1H3GPR119JAK2 | |
| SCHEMBL17821020 | 0.83 | CYP1A2 (0.44) | NTRK1NR1H2NR1H3GPR119JAK2 | |
| SCHEMBL23083856 | 0.83 | NTRK1 (0.44) | NTRK1NR1H2NR1H3GPR119 | |
| SCHEMBL18588911 | 0.83 | CYP1A2 (0.44) | NTRK1NR1H2NR1H3GPR119JAK2 | |
| SCHEMBL17820748 | 0.83 | NTRK1 (0.44) | NTRK1NR1H2NR1H3GPR119 | |
| SCHEMBL17820744 | 0.83 | NTRK1 (0.44) | NTRK1NR1H2NR1H3GPR119 | |
| SCHEMBL18588910 | 0.83 | CYP1A2 (0.44) | NTRK1NR1H2NR1H3GPR119JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233863-A1 | FUSED RING HETEROARYL COMPOUNDS AND THEIR USE AS TRK INHIBITORS | CMG Pharmaceutical Co., Ltd. (KR) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016097869-A1 | FUSED RING HETEROARYL COMPOUNDS AND THEIR USE AS TRK INHIBITORS | CMG PHARMACEUTICAL CO., LTD. (KR) | 2016-06-23 | — | — | WO | disclosed |