Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.45 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | CDK9 | P50750 | 2/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.44 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 8/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16017047 | 0.91 | FYN (0.43) | KCNH2MKNK1DYRK3CCNT1CCNA2 | |
| SCHEMBL16016920 | 0.91 | FYN (0.43) | KCNH2MKNK1DYRK3CCNT1CCNA2 | |
| SCHEMBL16016831 | 0.91 | PIK3CD (0.43) | KCNH2MKNK1DYRK3CCNT1CCNA2 | |
| SCHEMBL17849288 | 0.91 | PIK3CD (0.43) | KCNH2MKNK1DYRK3CCNT1CCNA2 | |
| SCHEMBL16016966 | 0.90 | PIK3CD (0.55) | KCNH2MKNK1DYRK3CCNT1CCNA2 | |
| SCHEMBL17849290 | 0.89 | MKNK1 (0.56) | KCNH2MKNK1DYRK3CCNT1CCNA2 | |
| SCHEMBL17849253 | 0.89 | MKNK1 (0.43) | KCNH2MKNK1DYRK3CCNT1CCNA2 | |
| SCHEMBL17849264 | 0.88 | MKNK1 (0.49) | KCNH2MKNK1DYRK3CCNT1CCNA2 | |
| SCHEMBL17849266 | 0.88 | MKNK1 (0.49) | KCNH2MKNK1DYRK3CCNT1CCNA2 | |
| SCHEMBL16016828 | 0.87 | FYN (0.45) | KCNH2MKNK1DYRK3CCNT1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160228437-A1 | MIXED LINEAGE KINASE INHIBITORS AND METHOD OF TREATMENTS | Califia Bio, Inc. | 2016-08-11 | — | — | US | disclosed |
| US-9370515-B2 | Mixed lineage kinase inhibitors and method of treatments | Califia Bio, Inc. (US) | 2016-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160228437-A1 | MIXED LINEAGE KINASE INHIBITORS AND METHOD OF TREATMENTS | MAP3K2, MAP3K1, MAP3K20 | KCNH2 2562/4885MKNK1 49/4885DYRK3 514/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.