Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12492603 | 0.85 | — | — | |
| SCHEMBL31746598 | 0.85 | — | — | |
| SCHEMBL17849528 | 0.81 | PTK2 (0.36) | PIK3C3CYP19A1ALOX5APFEN1KMT2A | |
| SCHEMBL17849522 | 0.80 | KMT2A (0.33) | PIK3C3CYP19A1ALOX5APFEN1KMT2A | |
| SCHEMBL26544597 | 0.72 | CYP19A1 (0.39) | CYP19A1KMT2A | |
| SCHEMBL2067485 | 0.69 | PIK3C3 (0.45) | PIK3C3CYP19A1ALOX5APFEN1KMT2A | |
| SCHEMBL12492065 | 0.68 | PIK3CB (0.42) | ALOX5APFEN1 | |
| SCHEMBL31746630 | 0.68 | PIK3CB (0.42) | ALOX5APFEN1 | |
| SCHEMBL2113176 | 0.67 | EDNRA (0.34) | CYP19A1 | |
| SCHEMBL25002905 | 0.67 | KMT2A (0.35) | CYP19A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9371319-B2 | Pyrrolopyridineamino derivatives as MPS1 inhibitors | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2016-06-21 | — | — | US | disclosed |