Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A2 | P19784 | 17/20 | 0.48 |
| ▸ | TYK2 | P29597 | 3/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 1/20 | 0.39 |
| ▸ | PHKG1 | Q16816 | 1/20 | 0.39 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | DAPK2 | Q9UIK4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2358177 | 0.89 | CSNK2A2 (0.62) | CSNK2A2TYK2STAT3CSNK2A1 | |
| SCHEMBL2356315 | 0.87 | CSNK2A2 (0.59) | CSNK2A2TYK2STAT3CSNK2A1CLK1 | |
| SCHEMBL3312315 | 0.87 | CSNK2A2 (0.46) | CSNK2A2TYK2STAT3CSNK2A1CLK1 | |
| SCHEMBL12013318 | 0.87 | CSNK2A2 (0.46) | CSNK2A2TYK2STAT3CSNK2A1CLK1 | |
| SCHEMBL3313753 | 0.87 | CSNK2A2 (0.39) | CSNK2A2TYK2STAT3CSNK2A1 | |
| SCHEMBL3313421 | 0.85 | CSNK2A2 (0.43) | CSNK2A2TYK2STAT3CSNK2A1CLK1 | |
| SCHEMBL3311734 | 0.84 | CSNK2A2 (0.48) | CSNK2A2CSNK2A1CLK1CLK2CDK7 | |
| SCHEMBL3311067 | 0.84 | CSNK2A2 (0.65) | CSNK2A2TYK2CSNK2A1CLK1CLK2 | |
| SCHEMBL3313209 | 0.84 | CSNK2A2 (0.53) | CSNK2A2CSNK2A1CLK1CLK2CDK7 | |
| SCHEMBL3312928 | 0.83 | CSNK2A2 (0.49) | CSNK2A2TYK2CSNK2A1CLK1CLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9371328-B2 | Imidazopyridazinecarbonitriles useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-06-21 | — | — | US | disclosed |
| US-9371328-B2 | Imidazopyridazinecarbonitriles useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-06-21 | — | — | US | disclosed |