Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 7/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | PRKDC | P78527 | 1/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 9/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 9/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2359655 | 0.96 | TYK2 (0.46) | TYK2PIK3CAMTORPRKDCSTAT3 | |
| SCHEMBL2358870 | 0.89 | CSNK2A2 (0.46) | TYK2STAT3CSNK2A2CSNK2A1CCNE1 | |
| SCHEMBL2358732 | 0.89 | TYK2 (0.42) | TYK2PIK3CAMTORPRKDCSTAT3 | |
| SCHEMBL2306697 | 0.85 | CSNK2A2 (0.49) | TYK2STAT3CSNK2A2CSNK2A1 | |
| SCHEMBL2358151 | 0.85 | TYK2 (0.44) | TYK2STAT3CSNK2A2CSNK2A1 | |
| SCHEMBL3313278 | 0.83 | TYK2 (0.53) | TYK2STAT3CSNK2A2CSNK2A1 | |
| SCHEMBL13641828 | 0.82 | TYK2 (0.49) | TYK2STAT3CSNK2A2CSNK2A1 | |
| SCHEMBL13641778 | 0.82 | TYK2 (0.42) | TYK2STAT3CSNK2A2CSNK2A1KCNH2 | |
| SCHEMBL2358888 | 0.82 | TYK2 (0.47) | TYK2STAT3CSNK2A2CSNK2A1 | |
| SCHEMBL11996498 | 0.81 | TYK2 (0.50) | TYK2STAT3CSNK2A2CSNK2A1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9371328-B2 | Imidazopyridazinecarbonitriles useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-06-21 | — | — | US | disclosed |