Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 5/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.46 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | CDK9 | P50750 | 2/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.41 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.37 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2358706 | 0.90 | TYK2 (0.51) | TYK2PDE4DDYRK3CCNT1CCNA2 | |
| SCHEMBL12012914 | 0.87 | TYK2 (0.53) | TYK2PDE4DCSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL3311950 | 0.81 | DYRK3 (0.46) | TYK2PDE4DDYRK3CCNT1CCNA2 | |
| SCHEMBL2358576 | 0.79 | TYK2 (0.37) | TYK2PDE4DMAPTMAPK1 | |
| SCHEMBL3316421 | 0.79 | TYK2 (0.58) | TYK2PDE4DDYRK3CDK2CSNK2A1 | |
| SCHEMBL3313651 | 0.78 | CSNK2A1 (0.58) | TYK2DYRK3CCNT1CCNA2CDK2 | |
| SCHEMBL2358072 | 0.76 | TYK2 (0.53) | TYK2PDE4DCSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL3307854 | 0.76 | TYK2 (0.52) | TYK2PDE4DDYRK2CSNK2A1CSNK2A2 | |
| SCHEMBL3313502 | 0.76 | TYK2 (0.52) | TYK2PDE4DCSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL12012925 | 0.76 | TYK2 (0.47) | TYK2PDE4DDYRK3CDK2DYRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9371328-B2 | Imidazopyridazinecarbonitriles useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-06-21 | — | — | US | disclosed |