Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10329125 | 1.00 | BACE1 (0.34) | BACE1BACE2 | |
| SCHEMBL20056424 | 0.94 | BACE1 (0.35) | BACE1BACE2 | |
| SCHEMBL17127209 | 0.93 | BACE1 (0.40) | BACE1BACE2 | |
| SCHEMBL17127222 | 0.90 | BACE1 (0.33) | BACE1BACE2 | |
| SCHEMBL17127211 | 0.90 | BACE1 (0.31) | BACE1BACE2 | |
| SCHEMBL17127208 | 0.89 | BACE1 (0.34) | BACE1BACE2 | |
| SCHEMBL10329019 | 0.88 | BACE1 (0.36) | BACE1BACE2 | |
| SCHEMBL17850161 | 0.88 | BACE1 (0.36) | BACE1BACE2 | |
| SCHEMBL17131148 | 0.87 | BACE1 (0.34) | BACE1BACE2 | |
| SCHEMBL17127215 | 0.87 | BACE1 (0.34) | BACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2908825-B1 | TRICYCLIC SUBSTITUTED THIADIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME (US) | 2018-04-18 | — | — | EP | disclosed |
| EP-3034080-A1 | IMINOTHIADIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE | Merck Sharp & Dohme Corp. (US) | 2016-06-22 | — | — | EP | disclosed |