Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 18/20 | 0.81 |
| ▸ | CCNE1 | P24864 | 15/20 | 0.81 |
| ▸ | CDK4 | P11802 | 8/20 | 0.81 |
| ▸ | CCND1 | P24385 | 8/20 | 0.81 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.60 |
| ▸ | CCND3 | P30281 | 1/20 | 0.60 |
| ▸ | CDK9 | P50750 | 1/20 | 0.60 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15249256 | 0.89 | CDK2 (1.00) | CDK2CCNE1CDK4CCND1CCNT1 | |
| SCHEMBL16074640 | 0.89 | CDK2 (1.00) | CDK2CCNE1CDK4CCND1CCNT1 | |
| SCHEMBL22005395 | 0.89 | CDK2 (1.00) | CDK2CCNE1CDK4CCND1CCNT1 | |
| SCHEMBL19041991 | 0.87 | CDK2 (0.77) | CDK2CCNE1CDK4CCND1CCNT1 | |
| SCHEMBL16088343 | 0.86 | CDK2 (1.00) | CDK2CCNE1CDK4CCND1CCNT1 | |
| SCHEMBL18493781 | 0.86 | CDK2 (1.00) | CDK2CCNE1CDK4CCND1CCNT1 | |
| SCHEMBL15249258 | 0.86 | CDK2 (1.00) | CDK2CCNE1CDK4CCND1CCNT1 | |
| SCHEMBL21388256 | 0.85 | CDK2 (0.83) | CDK2CCNE1CDK4CCND1CCND3 | |
| SCHEMBL15249253 | 0.85 | CDK2 (0.86) | CDK2CCNE1CDK4CCND1CCNT1 | |
| SCHEMBL15249263 | 0.84 | CDK2 (1.00) | CDK2CCNE1CDK4CCND1CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632467-B1 | CDK INHIBITORS | G1 THERAPEUTICS INC (US) | 2016-06-22 | — | — | EP | disclosed |