Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 4/20 | 0.38 |
| ▸ | GRM5 | P41594 | 3/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | BCR | P11274 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | CCNC | P24863 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10194969 | 0.92 | JAK2 (0.48) | GRM1GRM5JAK2MAPK14FLT3 | |
| SCHEMBL10195040 | 0.80 | TLR9 (0.41) | JAK2FLT3LRRK2 | |
| SCHEMBL10195036 | 0.80 | TLR9 (0.40) | JAK2FLT3LRRK2 | |
| SCHEMBL10195701 | 0.79 | FLT3 (0.53) | JAK2FLT3ALDH1A1HPGDNTRK1 | |
| SCHEMBL10194984 | 0.79 | CDC7 (0.44) | JAK2FLT3ALDH1A1MAPK8MAPK10 | |
| SCHEMBL10194782 | 0.78 | MAPK10 (0.53) | JAK2FLT3ALDH1A1HPGDNTRK1 | |
| SCHEMBL10195045 | 0.77 | GSK3B (0.40) | JAK2FLT3LRRK2 | |
| SCHEMBL10195024 | 0.77 | MAPK10 (0.52) | FLT3ALDH1A1HPGDMAP4K1MAPK8 | |
| SCHEMBL10195628 | 0.76 | LRRK2 (0.54) | JAK2FLT3CCNCCDK8LRRK2 | |
| SCHEMBL10194781 | 0.76 | JAK2 (0.49) | JAK2FLT3ALDH1A1HPGDABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655357-B1 | INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS | MERCK SERONO SA (CH) | 2016-06-22 | — | — | EP | disclosed |