Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.43 |
| ▸ | FLT3 | P36888 | 12/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10194802 | 0.84 | FLT3 (0.45) | LRRK2FLT3MAPK10JAK2PDPK1 | |
| SCHEMBL17850469 | 0.83 | FGFR1 (0.47) | LRRK2FLT3MAPK10JAK2PDPK1 | |
| SCHEMBL10194781 | 0.82 | JAK2 (0.49) | LRRK2FLT3MAPK10JAK2 | |
| SCHEMBL10194763 | 0.81 | JAK2 (0.50) | LRRK2FLT3MAPK10JAK2 | |
| SCHEMBL10194890 | 0.81 | AXL (0.50) | LRRK2FLT3MAPK10JAK2PDPK1 | |
| SCHEMBL10194698 | 0.80 | MAPK10 (0.49) | LRRK2FLT3MAPK10JAK2 | |
| SCHEMBL10194757 | 0.80 | JAK2 (0.49) | LRRK2FLT3MAPK10JAK2 | |
| SCHEMBL9951916 | 0.80 | JAK2 (0.49) | LRRK2FLT3MAPK10JAK2 | |
| SCHEMBL10194764 | 0.80 | JAK2 (0.49) | LRRK2FLT3MAPK10JAK2 | |
| SCHEMBL10194998 | 0.80 | FLT3 (0.44) | LRRK2FLT3MAPK10JAK2GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655357-B1 | INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS | MERCK SERONO SA (CH) | 2016-06-22 | — | — | EP | disclosed |