Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | MAP2K4 | P45985 | 9/20 | 0.37 |
| ▸ | MAP2K7 | O14733 | 2/20 | 0.35 |
| ▸ | ITK | Q08881 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.34 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.34 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10196959 | 1.00 | HTR2A (0.39) | HTR2AFGFR1FLT1KDRMAP2K4 | |
| SCHEMBL10194860 | 0.96 | FGFR1 (0.39) | HTR2AFGFR1FLT1KDRMAP2K4 | |
| SCHEMBL10194801 | 0.88 | GRM4 (0.39) | HTR2AFGFR1FLT1FLT3ADRA2A | |
| SCHEMBL10196871 | 0.88 | GRM4 (0.39) | HTR2AFGFR1FLT1FLT3ADRA2A | |
| SCHEMBL10194964 | 0.86 | P2RY14 (0.35) | ITKFLT3ADRA2AADRA2BADRA2C | |
| SCHEMBL10194983 | 0.85 | P2RY14 (0.47) | HTR2AMAP2K4ADRA2AADRA2BADRA2C | |
| SCHEMBL10194867 | 0.84 | GRM4 (0.38) | FGFR1FLT1FLT3ADRA2AADRA2B | |
| SCHEMBL15322358 | 0.84 | HTR2A (0.38) | HTR2AFGFR1FLT1KDRMAP2K4 | |
| SCHEMBL15317778 | 0.84 | HTR2A (0.38) | HTR2AFGFR1FLT1KDRMAP2K4 | |
| SCHEMBL10194743 | 0.80 | P2RY14 (0.39) | HTR2AFGFR1FLT1KDRADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655357-B1 | INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS | MERCK SERONO SA (CH) | 2016-06-22 | — | — | EP | disclosed |