Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 7/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21902891 | 1.00 | PDE4B (0.46) | PDE4BNR1H2NAMPTTACR1USP2 | |
| SCHEMBL24215540 | 1.00 | PDE4B (0.46) | PDE4BNR1H2NAMPTTACR1USP2 | |
| SCHEMBL709070 | 0.89 | PDE4B (0.42) | PDE4BNR1H2TACR1EPHX1MEN1 | |
| SCHEMBL18814080 | 0.86 | NR1H2 (0.43) | PDE4BNR1H2NAMPTTACR1USP2 | |
| SCHEMBL22331591 | 0.86 | NR1H2 (0.43) | PDE4BNR1H2NAMPTTACR1USP2 | |
| SCHEMBL20331899 | 0.86 | NR1H2 (0.43) | PDE4BNR1H2NAMPTTACR1USP2 | |
| SCHEMBL18814057 | 0.86 | NR1H2 (0.43) | PDE4BNR1H2NAMPTTACR1USP2 | |
| SCHEMBL1013664 | 0.83 | NR1H2 (0.52) | PDE4BNR1H2NAMPTTACR1USP2 | |
| SCHEMBL22035920 | 0.82 | NR1H2 (0.47) | PDE4BNR1H2NAMPTUSP2SMN1; SMN2 | |
| SCHEMBL21388760 | 0.82 | NR1H2 (0.47) | PDE4BNR1H2NAMPTUSP2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3719024-A1 | ARGINASE INHIBITORS AS THERAPEUTICS | Mars, Incorporated (US) | 2020-10-07 | — | — | EP | disclosed |
| EP-3034509-B1 | ARGINASE INHIBITORS AS THERAPEUTICS | MARS INC (US) | 2020-04-22 | — | — | EP | disclosed |
| EP-3034509-A1 | ARGINASE INHIBITORS AS THERAPEUTICS | Mars, Incorporated (US) | 2016-06-22 | — | — | EP | disclosed |