Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 19/20 | 0.88 |
| ▸ | ABL1 | P00519 | 4/20 | 0.88 |
| ▸ | BCR | P11274 | 4/20 | 0.88 |
| ▸ | FYN | P06241 | 2/20 | 0.88 |
| ▸ | WEE2 | P0C1S8 | 2/20 | 0.88 |
| ▸ | WEE1 | P30291 | 2/20 | 0.88 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.88 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.88 |
| ▸ | STK25 | O00506 | 1/20 | 0.88 |
| ▸ | CIT | O14578 | 1/20 | 0.88 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.88 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.88 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.88 |
| ▸ | CASK | O14936 | 1/20 | 0.88 |
| ▸ | GAK | O14976 | 1/20 | 0.88 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.88 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.88 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.88 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.88 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.88 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23746826 | 0.94 | SRC (0.88) | SRCABL1BCRFYNWEE2 | |
| Bosutinib SCHEMBL2887945 | 0.94 | SRC (1.00) | SRCABL1BCRFYNWEE2 | |
| Bosutinib SCHEMBL29389315 | 0.94 | SRC (1.00) | SRCABL1BCRFYNWEE2 | |
| Bosutinib SCHEMBL29428159 | 0.94 | SRC (1.00) | SRCABL1BCRFYNWEE2 | |
| Bosutinib SCHEMBL29350234 | 0.94 | SRC (1.00) | SRCABL1BCRFYNWEE2 | |
| Bosutinib SCHEMBL19207253 | 0.94 | SRC (1.00) | SRCABL1BCRFYNWEE2 | |
| Bosutinib SCHEMBL158390 | 0.94 | SRC (1.00) | SRCABL1BCRFYNWEE2 | |
| Bosutinib SCHEMBL19207270 | 0.92 | SRC (0.97) | SRCABL1BCRFYNWEE2 | |
| SCHEMBL10102563 | 0.91 | SRC (0.89) | SRCABL1BCRFYNWEE2 | |
| SCHEMBL13197902 | 0.91 | SRC (0.85) | SRCABL1BCRFYNWEE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230303499-A1 | INHIBITORS OF ACK1/TNK2 TYROSINE KINASE | NATIONAL INSTITUTES OF HEALTH | 2023-09-28 | — | — | US | disclosed |
| US-20180215738-A1 | INHIBITORS OF ACK1/TNK2 TYROSINE KINASE | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. | 2018-08-02 | — | — | US | disclosed |
| US-10017478-B2 | Inhibitors of ACK1/TNK2 tyrosine kinase | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2018-07-10 | — | — | US | disclosed |
| US-20180155297-A1 | INHIBITORS OF ACK1/TNK2 TYROSINE KINASE | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. | 2018-06-07 | — | — | US | disclosed |
| US-9850216-B2 | Inhibitors of ACK1/TNK2 tyrosine kinase | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2017-12-26 | — | — | US | disclosed |
| US-20160176826-A1 | INHIBITORS OF ACK1/TNK2 TYROSINE KINASE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160176826-A1 | INHIBITORS OF ACK1/TNK2 TYROSINE KINASE | TNK1, TNNI3K, TNK2 | SRC 415/4885ABL1 272/4885BCR 1209/4885 |
| US-10017478-B2 | Inhibitors of ACK1/TNK2 tyrosine kinase | TNK1, TNNI3K, TNK2 | SRC 415/4885ABL1 272/4885BCR 1209/4885 |
| US-20180155297-A1 | INHIBITORS OF ACK1/TNK2 TYROSINE KINASE | TNK1, TNNI3K, TNK2 | SRC 415/4885ABL1 272/4885BCR 1209/4885 |
| US-20230303499-A1 | INHIBITORS OF ACK1/TNK2 TYROSINE KINASE | TNK1, TNK2, TNNI3K | SRC 300/4885ABL1 224/4885BCR 931/4885 |
| US-20180215738-A1 | INHIBITORS OF ACK1/TNK2 TYROSINE KINASE | TNK1, TNNI3K, TNK2 | SRC 380/4885ABL1 252/4885BCR 1217/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.