Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 18/20 | 0.84 |
| ▸ | PIK3C2B | O00750 | 15/20 | 0.84 |
| ▸ | PIK3CG | P48736 | 11/20 | 0.84 |
| ▸ | MTOR | P42345 | 12/20 | 0.57 |
| ▸ | PIK3CB | P42338 | 10/20 | 0.57 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17857196 | 0.91 | PIK3CD (1.00) | PIK3CDPIK3C2BPIK3CGMTORPIK3CB | |
| SCHEMBL19760569 | 0.91 | PIK3CD (0.88) | PIK3CDPIK3C2BPIK3CGMTORPIK3CB | |
| SCHEMBL19760574 | 0.83 | PIK3CD (0.74) | PIK3CDPIK3C2BPIK3CGMTORPIK3CB | |
| SCHEMBL19736913 | 0.82 | PIK3CD (0.61) | PIK3CDPIK3C2BPIK3CGMTORPIK3CB | |
| SCHEMBL19760567 | 0.82 | PIK3CD (0.83) | PIK3CDPIK3C2BPIK3CGMTORPIK3CB | |
| SCHEMBL21120259 | 0.77 | PIK3CD (0.85) | PIK3CDPIK3C2BPIK3CGMTORPIK3CB | |
| SCHEMBL19736623 | 0.76 | PIK3CD (0.69) | PIK3CDPIK3C2BPIK3CGMTORPIK3CB | |
| SCHEMBL19736625 | 0.76 | PIK3CD (0.61) | PIK3CDPIK3C2BPIK3CGMTORPIK3CB | |
| SCHEMBL21120003 | 0.76 | PIK3CD (0.50) | PIK3CDPIK3C2BPIK3CGMTORPIK3CB | |
| SCHEMBL19736718 | 0.76 | PIK3CD (0.63) | PIK3CDPIK3C2BPIK3CGMTORPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233862-B1 | IMIDAZOPYRIDAZINE DERIVATIVES AS PI3KBETA INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-07-03 | — | — | EP | disclosed |
| WO-2016097347-A1 | IMIDAZOPYRIDAZINE DERIVATIVES AS ΡΙ3Κβ INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-06-23 | — | — | WO | disclosed |