Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C2B | O00750 | 18/20 | 0.61 |
| ▸ | PIK3CD | O00329 | 18/20 | 0.61 |
| ▸ | MTOR | P42345 | 16/20 | 0.61 |
| ▸ | PIK3CG | P48736 | 14/20 | 0.61 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19760613 | 0.92 | PIK3CD (0.62) | PIK3C2BPIK3CDMTORPIK3CGPIK3CB | |
| SCHEMBL19760540 | 0.91 | PIK3C2B (0.64) | PIK3C2BPIK3CDMTORPIK3CGPIK3CB | |
| SCHEMBL17857180 | 0.91 | PIK3C2B (0.62) | PIK3C2BPIK3CDMTORPIK3CGPIK3CB | |
| SCHEMBL19760603 | 0.91 | PIK3CD (0.55) | PIK3C2BPIK3CDMTORPIK3CGPIK3CB | |
| SCHEMBL19760618 | 0.89 | PIK3CD (0.64) | PIK3C2BPIK3CDMTORPIK3CGPIK3CB | |
| SCHEMBL17857409 | 0.86 | PIK3CD (0.81) | PIK3C2BPIK3CDMTORPIK3CGPIK3CB | |
| SCHEMBL21386305 | 0.86 | PIK3C2B (0.56) | PIK3C2BPIK3CDMTORPIK3CGPIK3CB | |
| SCHEMBL19760612 | 0.85 | PIK3C2B (0.53) | PIK3C2BPIK3CDMTORPIK3CGPIK3CB | |
| SCHEMBL19760614 | 0.85 | PIK3CD (0.56) | PIK3C2BPIK3CDMTORPIK3CGPIK3CB | |
| SCHEMBL19913073 | 0.83 | PIK3C2B (0.63) | PIK3C2BPIK3CDMTORPIK3CGPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233839-B1 | HETEROCYCLYL LINKED IMIDAZOPYRIDAZINE DERIVATIVES AS PI3KBETA INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-09-25 | — | — | EP | disclosed |
| EP-3233862-B1 | IMIDAZOPYRIDAZINE DERIVATIVES AS PI3KBETA INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-07-03 | — | — | EP | disclosed |
| WO-2016097347-A1 | IMIDAZOPYRIDAZINE DERIVATIVES AS ΡΙ3Κβ INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-06-23 | — | — | WO | disclosed |
| WO-2016097359-A1 | HETEROCYCLYL LINKED IMIDAZOPYRIDAZINE DERIVATIVES AS PI3KBETA INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-06-23 | — | — | WO | disclosed |