Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 9/20 | 0.47 |
| ▸ | PIK3C2B | O00750 | 9/20 | 0.47 |
| ▸ | MTOR | P42345 | 9/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.47 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21120181 | 0.86 | KMT2A (0.48) | CRHBPCRHR2KMT2AALDH1A1HTT | |
| SCHEMBL17857351 | 0.83 | KMT2A (0.46) | CRHBPCRHR2KMT2AALDH1A1HTT | |
| SCHEMBL21120183 | 0.81 | KMT2A (0.43) | CRHBPCRHR2PIK3CDMTORPIK3CG | |
| SCHEMBL19760565 | 0.80 | HTT (0.47) | CRHBPCRHR2KMT2AALDH1A1HTT | |
| SCHEMBL2575429 | 0.75 | SMPD3 (0.52) | CRHBPCRHR2SMPD3KMT2AALDH1A1 | |
| SCHEMBL17857220 | 0.73 | PIK3CD (0.59) | PIK3CDPIK3C2BMTORPIK3CGPIK3CA | |
| SCHEMBL25341891 | 0.73 | MAPT (0.42) | CRHBPCRHR2PIK3CDPIK3C2BMTOR | |
| SCHEMBL17857329 | 0.73 | SMN1; SMN2 (0.42) | CRHBPCRHR2PIK3CDPIK3C2BMTOR | |
| SCHEMBL17232705 | 0.72 | SMN1; SMN2 (0.47) | CRHBPCRHR2KMT2AALDH1A1HTT | |
| SCHEMBL2584005 | 0.72 | PDE10A (0.53) | SMPD3KMT2AMAPTCYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233862-B1 | IMIDAZOPYRIDAZINE DERIVATIVES AS PI3KBETA INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-07-03 | — | — | EP | disclosed |
| US-20180002336-A1 | IMIDAZOPYRIDAZINE DERIVATIVES AS PI3KB INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-01-04 | — | — | US | disclosed |
| WO-2016097347-A1 | IMIDAZOPYRIDAZINE DERIVATIVES AS ΡΙ3Κβ INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180002336-A1 | IMIDAZOPYRIDAZINE DERIVATIVES AS PI3KB INHIBITORS | PIK3CB, PIK3CD, PIK3CA | CRHBP 3851/4885CRHR2 4657/4885PIK3CD 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.