Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 20/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17857737 | 1.00 | SYK (0.61) | SYK | |
| SCHEMBL16778193 | 0.90 | SYK (0.60) | SYK | |
| SCHEMBL16778121 | 0.90 | SYK (0.60) | SYK | |
| SCHEMBL16737677 | 0.86 | SYK (0.65) | SYK | |
| SCHEMBL17857732 | 0.83 | SYK (0.61) | SYK | |
| SCHEMBL17857734 | 0.83 | SYK (0.61) | SYK | |
| SCHEMBL20377659 | 0.83 | SYK (0.61) | SYK | |
| SCHEMBL16737328 | 0.82 | SYK (0.71) | SYK | |
| SCHEMBL16737824 | 0.82 | SYK (0.58) | SYK | |
| SCHEMBL16737613 | 0.81 | SYK (0.69) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2863916-B1 | SUBSTITUTED PYRIDINE SPLEEN TYROSINE KINASE (SYK) INHIBITORS | MERCK SHARP & DOHME (US) | 2018-07-18 | — | — | EP | claimed |
| US-9376418-B2 | Substituted pyridine spleen tyrosine kinase (SYK) inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-06-28 | — | — | US | claimed |