Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 10/20 | 0.46 |
| ▸ | GRM5 | P41594 | 9/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.42 |
| ▸ | LIPC | P11150 | 1/20 | 0.41 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17838003 | 0.85 | GRM1 (0.50) | GRM1GRM5CYP11B2PDK4JAK1 | |
| SCHEMBL17837639 | 0.80 | GRM1 (0.57) | GRM1GRM5PDK4JAK1GPR119 | |
| SCHEMBL17837379 | 0.75 | GRM1 (0.48) | GRM1GRM5CYP11B2PDK4LIPC | |
| SCHEMBL30023252 | 0.75 | GRM1 (0.48) | GRM1GRM5CYP11B2PDK4JAK1 | |
| SCHEMBL24597336 | 0.73 | GRM1 (0.51) | GRM1GRM5CYP11B2PDK4JAK1 | |
| SCHEMBL17838317 | 0.73 | GRM1 (0.51) | GRM1GRM5CYP11B2PDK4JAK1 | |
| SCHEMBL12537891 | 0.73 | GRM1 (0.51) | GRM1GRM5CYP11B2PDK4GPR119 | |
| SCHEMBL30567529 | 0.73 | GRM1 (0.51) | GRM1GRM5CYP11B2PDK4JAK1 | |
| SCHEMBL30308912 | 0.73 | GRM1 (0.64) | GRM1GRM5PDK4JAK1GPR119 | |
| SCHEMBL17837612 | 0.72 | GRM1 (0.53) | GRM1GRM5PDK4JAK1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016097918-A1 | PYRIMIDINE AND TRIAZINE DERIVATIVES AND THEIR USE AS AXL INHIBITORS | PFIZER INC. (US) | 2016-06-23 | — | — | WO | disclosed |