SCHEMBL17857845

SCHEMBL17857845

COc1cnc(Br)c2[nH]cc(C(=O)C(=O)N3CCN(C(=O)I)CC3)c12

nearest known ligand 0.58

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 2/20 0.58
CYP3A4 P08684 2/20 0.51
CYP2D6 P10635 2/20 0.51
CYP1A2 P05177 1/20 0.51
CYP2C8 P10632 1/20 0.51
CYP2B6 P20813 1/20 0.51
CYP2C19 P33261 1/20 0.51
KCNH2 Q12809 1/20 0.51
CNR2 P34972 1/20 0.32
CHRNB2 P17787 1/20 0.31
CHRNA4 P43681 1/20 0.31
GABRA1 P14867 1/20 0.31
GABRG2 P18507 1/20 0.31
GABRB3 P28472 1/20 0.31
GABRA3 P34903 1/20 0.31
GABRA2 P47869 1/20 0.31
GABRB2 P47870 1/20 0.31
POLB P06746 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16438149 0.93 CYP2C9 (0.59) CYP2C9CYP3A4CYP2D6CYP1A2CYP2C8
SCHEMBL15164817 0.90 CYP2C9 (0.59) CYP2C9CYP3A4CYP2D6CYP1A2CYP2C8
SCHEMBL16440230 0.89 CYP2C9 (0.58) CYP2C9CYP3A4CYP2D6CYP1A2CYP2C8
SCHEMBL12456007 0.85 CYP2C9 (0.81) CYP2C9CYP3A4CYP2D6CYP1A2CYP2C8
SCHEMBL17955371 0.82 CYP2C9 (0.48) CYP2C9CYP3A4CYP2D6CYP1A2CYP2C8
SCHEMBL12215447 0.81 CYP2C9 (0.44) CYP2C9CYP3A4CYP2D6CYP1A2CYP2C8
SCHEMBL30940373 0.81 CYP2C9 (0.59) CYP2C9CYP3A4CYP2D6CYP1A2CYP2C8
SCHEMBL30940370 0.81 CYP2C9 (0.59) CYP2C9CYP3A4CYP2D6CYP1A2CYP2C8
SCHEMBL12215230 0.81 CYP2C9 (0.54) CYP2C9CYP3A4CYP2D6CYP1A2CYP2C8
SCHEMBL10077421 0.80 CYP2C9 (0.62) CYP2C9CYP3A4CYP2D6CYP1A2CYP2C8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016100651-A1 A PROCESS FOR PREPARING HALOGENATED AZAINDOLE COMPOUNDS USING PYBROP BRISTOL-MYERS SQUIBB COMPANY (US) 2016-06-23 WO disclosed