Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 20/20 | 0.71 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17843236 | 0.88 | NR1H4 (0.55) | NR1H4HSD17B13 | |
| SCHEMBL28912135 | 0.88 | NR1H4 (0.75) | NR1H4HSD17B13 | |
| SCHEMBL17858834 | 0.87 | NR1H4 (0.76) | NR1H4HSD17B13 | |
| SCHEMBL19122445 | 0.87 | NR1H4 (0.72) | NR1H4HSD17B13 | |
| SCHEMBL19202154 | 0.87 | NR1H4 (0.72) | NR1H4HSD17B13 | |
| SCHEMBL17843279 | 0.86 | NR1H4 (0.68) | NR1H4HSD17B13 | |
| SCHEMBL19122446 | 0.85 | NR1H4 (0.71) | NR1H4HSD17B13 | |
| SCHEMBL19122604 | 0.85 | NR1H4 (0.71) | NR1H4HSD17B13 | |
| SCHEMBL17858835 | 0.85 | NR1H4 (0.87) | NR1H4HSD17B13 | |
| SCHEMBL17843231 | 0.85 | NR1H4 (0.87) | NR1H4HSD17B13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107108595-B | Novel FXR (NR1H4) modulating compounds | 吉利德科学公司 | 2021-04-06 | — | — | CN | disclosed |
| EP-3233831-B1 | NOVEL FXR (NR1H4) MODULATING COMPOUNDS | GILEAD SCIENCES INC (US) | 2019-02-20 | — | — | EP | disclosed |
| WO-2016096116-A1 | NOVEL FXR (NR1H4) MODULATING COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2016-06-23 | — | — | WO | disclosed |