Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | MMP1 | P03956 | 2/20 | 0.43 |
| ▸ | MMP2 | P08253 | 2/20 | 0.43 |
| ▸ | MMP9 | P14780 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17848304 | 0.94 | PPARG (0.52) | PPARGUSP2NLRP3KMT2AHPGD | |
| SCHEMBL17848307 | 0.94 | PPARG (0.52) | PPARGUSP2NLRP3KMT2AHPGD | |
| SCHEMBL17848187 | 0.92 | PPARG (0.62) | PPARGUSP2SMN1; SMN2 | |
| SCHEMBL17848189 | 0.92 | PPARG (0.62) | PPARGUSP2SMN1; SMN2 | |
| SCHEMBL17848273 | 0.89 | PPARG (0.46) | PPARGUSP2NLRP3KMT2AMEN1 | |
| SCHEMBL17848245 | 0.89 | PPARG (0.46) | PPARGUSP2NLRP3KMT2AMEN1 | |
| SCHEMBL17859159 | 0.88 | PPARG (0.60) | PPARGNLRP3SMN1; SMN2 | |
| SCHEMBL17821305 | 0.88 | PPARG (0.48) | PPARGUSP2KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL17821303 | 0.88 | PPARG (0.48) | PPARGUSP2KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL17848301 | 0.85 | PPARG (0.53) | PPARGUSP2KMT2AHPGDMMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016099452-A1 | RAS-INHIBITING INDENYL ACETAMIDE COMPOUNDS, COMPOSITIONS, AND USES | ADT PHARMACEUTICALS, INC. (US) | 2016-06-23 | — | — | WO | disclosed |