Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 20/20 | 0.51 |
| ▸ | HCRTR2 | O43614 | 20/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19755200 | 0.84 | HCRTR1 (0.58) | HCRTR1HCRTR2 | |
| SCHEMBL19741881 | 0.71 | PDE8B (0.33) | HCRTR1HCRTR2 | |
| SCHEMBL27055583 | 0.70 | CHRNA7 (0.41) | — | |
| SCHEMBL27055543 | 0.70 | CHRNA7 (0.41) | — | |
| SCHEMBL27055584 | 0.69 | HCRTR1 (0.34) | HCRTR1HCRTR2 | |
| SCHEMBL27055605 | 0.69 | HRH4 (0.40) | HCRTR1HCRTR2 | |
| SCHEMBL27030018 | 0.69 | HCRTR1 (0.34) | HCRTR1HCRTR2 | |
| SCHEMBL27055610 | 0.69 | HRH4 (0.40) | HCRTR1HCRTR2 | |
| SCHEMBL19742027 | 0.69 | HCRTR1 (0.60) | HCRTR1HCRTR2 | |
| SCHEMBL19742026 | 0.69 | HCRTR1 (0.60) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9987255-B2 | 5,5-bicyclic oxazole orexin receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2018-06-05 | — | — | US | disclosed |
| US-20170368035-A1 | 5,5-Bicyclic Oxazole Orexin Receptor Antagonists | MERCK SHARP & DOHME LLC | 2017-12-28 | — | — | US | disclosed |
| WO-2016100162-A2 | 5,5-BICYCLIC OXAZOLE OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2016-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170368035-A1 | 5,5-Bicyclic Oxazole Orexin Receptor Antagonists | HCRTR2, HCRTR1, NPY5R | HCRTR1 2/4885HCRTR2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.