Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 2/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.37 |
| ▸ | SPR | P35270 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 2/20 | 0.34 |
| ▸ | DYRK2 | Q92630 | 3/20 | 0.34 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 2/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17844722 | 0.90 | PAK4 (0.43) | PAK4GABRA5SPRSTAT3HPGD | |
| SCHEMBL17844684 | 0.85 | PAK4 (0.42) | PAK4GABRA5SPRSTAT3DDR1 | |
| SCHEMBL18328792 | 0.84 | PAK4 (0.53) | PAK4NTRK1GABRA5STAT3RORC | |
| SCHEMBL17859531 | 0.84 | NTRK1 (0.40) | PAK4NTRK1GABRA5CACNA1HCACNA1B | |
| SCHEMBL17859532 | 0.84 | PAK4 (0.41) | PAK4NTRK1GABRA5STAT3HPGD | |
| SCHEMBL17844711 | 0.82 | PAK4 (0.62) | PAK4GABRA5SPRSTAT3HPGD | |
| SCHEMBL17844712 | 0.82 | PAK4 (0.62) | PAK4GABRA5SPRSTAT3HPGD | |
| SCHEMBL17859500 | 0.81 | PAK4 (0.38) | PAK4NTRK1GABRA5STAT3HPGD | |
| SCHEMBL16379571 | 0.81 | PAK4 (0.44) | PAK4NTRK1GABRA5STAT3HPGD | |
| SCHEMBL18541386 | 0.80 | PAK4 (0.37) | PAK4LRRK2NAMPTPAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016100515-A1 | CYCLIC COMPOUNDS AND USES THEREOF | Karyopharm Therapeutics Inc. (US) | 2016-06-23 | — | — | WO | disclosed |