Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19349201 | 1.00 | MAPK1 (0.32) | MAPK1 | |
| SCHEMBL17864286 | 0.84 | SLC6A2 (0.42) | MAPK1 | |
| SCHEMBL19381820 | 0.81 | MAPK1 (0.33) | MAPK1 | |
| SCHEMBL19368197 | 0.77 | MAPK1 (0.32) | MAPK1 | |
| SCHEMBL17864291 | 0.76 | KDM1A (0.49) | MAPK1 | |
| SCHEMBL20656923 | 0.75 | KDM1A (0.45) | — | |
| SCHEMBL20656924 | 0.75 | KDM1A (0.45) | — | |
| SCHEMBL21535772 | 0.71 | KDM4E (0.41) | — | |
| SCHEMBL23269920 | 0.67 | MAOB (0.54) | — | |
| SCHEMBL16649958 | 0.67 | MAOB (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016100050-A1 | ERK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-06-23 | — | — | WO | disclosed |
| WO-2016095089-A1 | ERK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-06-23 | — | — | WO | disclosed |