Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAE1 | Q13564 | 15/20 | 0.55 |
| ▸ | UBA3 | Q8TBC4 | 13/20 | 0.55 |
| ▸ | UBA6 | A0AVT1 | 3/20 | 0.55 |
| ▸ | CA2 | P00918 | 2/20 | 0.55 |
| ▸ | SAE1 | Q9UBE0 | 2/20 | 0.55 |
| ▸ | GRK5 | P34947 | 1/20 | 0.55 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.55 |
| ▸ | NEDD8 | Q15843 | 1/20 | 0.55 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10005114 | 1.00 | NAE1 (0.55) | NAE1UBA3UBA6CA2SAE1 | |
| SCHEMBL192677 | 0.95 | NAE1 (0.57) | NAE1UBA3UBA6CA2SAE1 | |
| SCHEMBL17865945 | 0.92 | NAE1 (0.54) | NAE1UBA3UBA6CA2SAE1 | |
| SCHEMBL10005007 | 0.92 | NAE1 (0.54) | NAE1UBA3UBA6CA2SAE1 | |
| SCHEMBL17865991 | 0.90 | NAE1 (0.58) | NAE1UBA3UBA6CA2SAE1 | |
| SCHEMBL17865927 | 0.90 | NAE1 (0.57) | NAE1UBA3UBA6CA2SAE1 | |
| SCHEMBL17865969 | 0.90 | NAE1 (0.57) | NAE1UBA3UBA6CA2SAE1 | |
| SCHEMBL5456241 | 0.90 | NAE1 (0.57) | NAE1UBA3UBA6CA2SAE1 | |
| SCHEMBL191800 | 0.90 | NAE1 (0.57) | NAE1UBA3UBA6CA2SAE1 | |
| SCHEMBL17865996 | 0.90 | NAE1 (0.56) | NAE1UBA3UBA6CA2SAE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402334-B1 | Inhibitors of E1 Activating Enzymes | MILLENNIUM PHARM INC (US) | 2016-06-29 | — | — | EP | claimed |