Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.67 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | ACHE | P22303 | 2/20 | 0.51 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.51 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL144484 | 0.81 | JAK2 (0.80) | JAK2DYRK1AALDH1A1KDM4EHPGD | |
| SCHEMBL140533 | 0.81 | JAK2 (1.00) | JAK2DYRK1AALDH1A1HPGDACHE | |
| SCHEMBL178818 | 0.79 | JAK2 (0.65) | JAK2DYRK1AALDH1A1KDM4EHPGD | |
| SCHEMBL23150357 | 0.73 | DYRK1A (1.00) | DYRK1AALDH1A1KDM4EHPGDACHE | |
| SCHEMBL9133082 | 0.73 | JAK2 (0.54) | JAK2ALDH1A1KDM4EHPGDCYP1A2 | |
| SCHEMBL16103012 | 0.72 | DYRK1A (0.76) | DYRK1AALDH1A1KDM4EHPGDACHE | |
| SCHEMBL30939947 | 0.72 | DYRK1A (0.76) | DYRK1AALDH1A1KDM4EHPGDACHE | |
| SCHEMBL142655 | 0.72 | JAK2 (0.78) | JAK2DYRK1AALDH1A1KDM4EHPGD | |
| SCHEMBL16102894 | 0.71 | DYRK1A (0.74) | DYRK1AALDH1A1KDM4EHPGDACHE | |
| SCHEMBL16123495 | 0.71 | DYRK1A (0.74) | DYRK1AALDH1A1KDM4EHPGDACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120058988-A1 | CARBAZOLE AND CARBOLINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120058988-A1 | CARBAZOLE AND CARBOLINE KINASE INHIBITORS | JAK2, JAK1, JAK3 | JAK2 1/4885DYRK1A 317/4885ALDH1A1 1464/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.