Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22776149 | 0.84 | CHEK1 (0.45) | CHEK1SLC6A2SLC6A4USP2SMN1; SMN2 | |
| SCHEMBL734651 | 0.84 | CHEK1 (0.45) | CHEK1SLC6A2SLC6A4USP2SMN1; SMN2 | |
| SCHEMBL4146870 | 0.84 | CHEK1 (0.45) | CHEK1SLC6A2SLC6A4USP2SMN1; SMN2 | |
| SCHEMBL1501987 | 0.83 | SLC6A2 (0.51) | CHEK1SLC6A2SLC6A4ADRA2CUSP2 | |
| SCHEMBL16036125 | 0.83 | SLC6A2 (0.51) | CHEK1SLC6A2SLC6A4ADRA2CUSP2 | |
| Hydrochloric Acid SCHEMBL19692370 | 0.83 | CHEK1 (0.44) | CHEK1SLC6A2SLC6A4USP2SMN1; SMN2 | |
| SCHEMBL27326370 | 0.83 | SLC6A2 (0.51) | CHEK1SLC6A2SLC6A4ADRA2CUSP2 | |
| SCHEMBL16035265 | 0.81 | USP2 (0.41) | CHEK1SLC6A2SLC6A4USP2SMN1; SMN2 | |
| SCHEMBL28204462 | 0.81 | USP2 (0.41) | CHEK1SLC6A2SLC6A4USP2SMN1; SMN2 | |
| SCHEMBL16035263 | 0.81 | USP2 (0.41) | CHEK1SLC6A2SLC6A4USP2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029539-B1 | N-(piperidinyl)-urea derivatives as inhibitors of soluble epoxide hydrolase for the treatment of e.g. hypertension or inflammations | UNIV CALIFORNIA (US) | 2016-06-29 | — | — | EP | disclosed |