Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | SLC6A12 | P48065 | 3/20 | 0.41 |
| ▸ | SLC6A11 | P48066 | 3/20 | 0.41 |
| ▸ | SLC6A13 | Q9NSD5 | 3/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.37 |
| ▸ | OGFRL1 | Q5TC84 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | CDC25A | P30304 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3708800 | 1.00 | RET (0.51) | RETMAPK14CAMK1DHDAC6S1PR1 | |
| SCHEMBL1788712 | 1.00 | RET (0.51) | RETMAPK14CAMK1DHDAC6S1PR1 | |
| SCHEMBL3708801 | 1.00 | RET (0.51) | RETMAPK14CAMK1DHDAC6S1PR1 | |
| SCHEMBL1788714 | 1.00 | RET (0.51) | RETMAPK14CAMK1DHDAC6S1PR1 | |
| SCHEMBL3701769 | 0.85 | RET (0.51) | RETMAPK14CAMK1DHDAC6S1PR1 | |
| SCHEMBL3701767 | 0.85 | RET (0.51) | RETMAPK14CAMK1DHDAC6S1PR1 | |
| SCHEMBL11603418 | 0.85 | RET (0.41) | RETMAPK14CAMK1DHDAC6S1PR1 | |
| SCHEMBL11604288 | 0.82 | RET (0.49) | RETMAPK14CAMK1DHDAC6S1PR1 | |
| SCHEMBL59970 | 0.80 | RET (0.47) | RETMAPK14CAMK1DHDAC6S1PR1 | |
| SCHEMBL61209 | 0.80 | RET (0.47) | RETMAPK14CAMK1DHDAC6S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8629143-B2 | Potassium channel modulators | ABBVIE INC. (US) | 2014-01-14 | — | — | US | disclosed |
| US-20110124642-A1 | POTASSIUM CHANNEL MODULATORS | ABBOTT LABORATORIES (US) | 2011-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110124642-A1 | POTASSIUM CHANNEL MODULATORS | KCNQ1, KCNQ2, KCNQ3 | RET 3302/4885MAPK14 3195/4885CAMK1D 663/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.