Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 19/20 | 0.75 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.75 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.41 |
| ▸ | MAPK6 | Q16659 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17837220 | 0.90 | MAPK1 (0.77) | MAPK1MAPK3MAP3K14MAPK6 | |
| SCHEMBL23141477 | 0.89 | MAPK1 (0.73) | MAPK1MAPK3MAP3K14MAPK6 | |
| SCHEMBL17881939 | 0.88 | MAPK1 (0.75) | MAPK1MAPK3MAP3K14MAPK6 | |
| SCHEMBL23141722 | 0.88 | MAPK1 (0.72) | MAPK1MAPK3MAP3K14 | |
| SCHEMBL23528176 | 0.86 | MAPK1 (0.69) | MAPK1MAPK3MAPK6 | |
| Temuterkib SCHEMBL17837273 | 0.86 | MAPK1 (1.00) | MAPK1MAPK3MAP3K14MAPK6 | |
| SCHEMBL23141595 | 0.85 | MAPK1 (0.68) | MAPK1MAPK3MAP3K14 | |
| SCHEMBL17837212 | 0.85 | MAPK1 (0.86) | MAPK1MAPK3MAP3K14MAPK6 | |
| SCHEMBL17837237 | 0.85 | MAPK1 (0.70) | MAPK1MAPK3MAP3K14MAPK6 | |
| SCHEMBL17837170 | 0.85 | MAPK1 (0.69) | MAPK1MAPK3MAP3K14MAPK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3237423-B1 | THIENO[2,3-C]PYRROL-4-ONE DERIVATIVES AS ERK INHIBITORS | LILLY CO ELI (US) | 2019-06-05 | — | — | EP | disclosed |
| EP-3237423-A1 | THIENO[2,3-C]PYRROL-4-ONE DERIVATIVES AS ERK INHIBITORS | Eli Lilly and Company (US) | 2017-11-01 | — | — | EP | disclosed |
| WO-2016106029-A1 | THIENO[2,3-C]PYRROL-4-ONE DERIVATIVES AS ERK INHIBITORS | ELI LILLY AND COMPANY (US) | 2016-06-30 | — | — | WO | disclosed |