Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 4/20 | 0.32 |
| ▸ | TNK2 | Q07912 | 4/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MERTK | Q12866 | 2/20 | 0.31 |
| ▸ | SGK1 | O00141 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1787367 | 0.93 | TNK2 (0.36) | EGFRCHRNB4CHRNA3CHRNB2CHRNA4 | |
| Formic Acid SCHEMBL1787516 | 0.92 | CHRNB4 (0.36) | EGFRCHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL1787145 | 0.91 | CHRNB4 (0.38) | EGFRCHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL14467158 | 0.91 | CHRNB4 (0.38) | EGFRCHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL1787239 | 0.86 | KDM4E (0.41) | EGFRCHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL14467476 | 0.86 | KDM4E (0.41) | EGFRCHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL1787400 | 0.84 | EGFR (0.34) | EGFRLCKTNK2JAK2SRC | |
| SCHEMBL1786857 | 0.84 | TNK2 (0.43) | EGFRLCKTNK2JAK2SRC | |
| SCHEMBL1784266 | 0.84 | TNK2 (0.43) | EGFRLCKTNK2JAK2SRC | |
| SCHEMBL1785065 | 0.84 | LCK (0.41) | EGFRLCKTNK2JAK2SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324222-B2 | Cyclically substituted furopyrimidine derivatives and use thereof | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2012-12-04 | — | — | US | disclosed |
| US-20110124665-A1 | Novel, Cyclically Substituted Furopyrimidine Derivatives and Use Thereof | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110124665-A1 | Novel, Cyclically Substituted Furopyrimidine Derivatives and Use Thereof | DPYD, TK2, TPMT | EGFR 4141/4885CHRNB4 4839/4885CHRNA3 4817/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.