Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.40 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17877755 | 0.76 | MAPT (0.48) | MAPTMAOBKDM4ESMN1; SMN2NPC1 | |
| SCHEMBL16430184 | 0.75 | KDM4E (0.60) | MAPTMAOBKDM4ESMN1; SMN2NPC1 | |
| SCHEMBL16431414 | 0.74 | MAPT (0.46) | MAPTMAOBKDM4ESMN1; SMN2NPC1 | |
| SCHEMBL10112833 | 0.73 | ERN1 (0.38) | KDM4EALDH1A1MEN1ERN1POLB | |
| SCHEMBL16430818 | 0.71 | KDM4E (0.41) | MAPTMAOBKDM4ESMN1; SMN2NPC1 | |
| SCHEMBL16431007 | 0.70 | MAPT (0.49) | MAPTMAOBKDM4ESMN1; SMN2NPC1 | |
| SCHEMBL12326165 | 0.68 | MAPT (0.56) | MAPTMAOBKDM4ESMN1; SMN2NPC1 | |
| SCHEMBL29697785 | 0.68 | MAPT (0.56) | MAPTMAOBKDM4ESMN1; SMN2NPC1 | |
| SCHEMBL8387066 | 0.68 | MAPT (0.48) | MAPTMAOBKDM4ESMN1; SMN2NPC1 | |
| SCHEMBL8390535 | 0.68 | MAPT (0.48) | MAPTMAOBKDM4ESMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9981970-B2 | Bicyclic ureas and thiadiazolidine-1, 1-dioxides as CETP inhibitors | MERCK SHARP & DOHME CORP. (US) | 2018-05-29 | — | — | US | disclosed |
| US-20160185784-A1 | BICYCLIC UREAS AND THIADIAZOLIDINE-1, 1-DIOXIDES AS CETP INHIBITORS | MERCK SHARP & DOHME LLC | 2016-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160185784-A1 | BICYCLIC UREAS AND THIADIAZOLIDINE-1, 1-DIOXIDES AS CETP INHIBITORS | CETP, CES1, PON1 | MAPT 1903/4885MAOB 949/4885KDM4E 2206/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.