Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 7/20 | 0.66 |
| ▸ | CCNH | P51946 | 7/20 | 0.66 |
| ▸ | MNAT1 | P51948 | 7/20 | 0.66 |
| ▸ | CDK2 | P24941 | 4/20 | 0.66 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.66 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.66 |
| ▸ | CDK9 | P50750 | 1/20 | 0.66 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.66 |
| ▸ | MELK | Q14680 | 2/20 | 0.60 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.60 |
| ▸ | PAK4 | O96013 | 13/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31220815 | 0.93 | CDK7 (0.78) | CDK7CCNHMNAT1CDK2CCNT1 | |
| SCHEMBL20741170 | 0.93 | CDK7 (0.78) | CDK7CCNHMNAT1CDK2CCNT1 | |
| SCHEMBL17877936 | 0.93 | CDK7 (0.78) | CDK7CCNHMNAT1CDK2CCNT1 | |
| SCHEMBL20741190 | 0.80 | CDK7 (1.00) | CDK7CCNHMNAT1CDK2CCNT1 | |
| SCHEMBL17878720 | 0.80 | CDK7 (1.00) | CDK7CCNHMNAT1CDK2CCNT1 | |
| SCHEMBL20741166 | 0.79 | CDK7 (0.85) | CDK7CCNHMNAT1CDK2CCNT1 | |
| SCHEMBL17878659 | 0.79 | CDK7 (0.85) | CDK7CCNHMNAT1CDK2CCNT1 | |
| SCHEMBL20741120 | 0.79 | CDK7 (0.78) | CDK7CCNHMNAT1CDK2CCNT1 | |
| SCHEMBL17878752 | 0.79 | CDK7 (0.62) | CDK7CCNHMNAT1CDK2CCNT1 | |
| SCHEMBL20741169 | 0.79 | CDK7 (0.62) | CDK7CCNHMNAT1CDK2CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016105528-A2 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2016-06-30 | — | — | WO | disclosed |