SCHEMBL17886835

SCHEMBL17886835

c1ccc(C2C[C@@H]2C2=NCCN2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NISCH Q9Y2I1 8/20 1.00
MAOA P21397 3/20 1.00
MAOB P27338 3/20 1.00
ADRA2A P08913 7/20 0.55
CACNA1F O60840 1/20 0.49
AR P10275 1/20 0.49
PDE4A P27815 1/20 0.49
SCN1A P35498 1/20 0.49
SCN4A P35499 1/20 0.49
SCN7A Q01118 1/20 0.49
CACNA1D Q01668 1/20 0.49
KCNH2 Q12809 1/20 0.49
CACNA1S Q13698 1/20 0.49
CACNA1C Q13936 1/20 0.49
SCN5A Q14524 1/20 0.49
SCN9A Q15858 1/20 0.49
SCN2A Q99250 1/20 0.49
SCN3A Q9NY46 1/20 0.49
SCN11A Q9UI33 1/20 0.49
SCN8A Q9UQD0 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17886752 1.00 NISCH (1.00) NISCHMAOAMAOBADRA2ACACNA1F
SCHEMBL2261976 0.73 MAOB (0.65) NISCHMAOAMAOBADRA2AKCNH2
SCHEMBL10540521 0.73 MAOB (0.65) NISCHMAOAMAOBADRA2AKCNH2
SCHEMBL8845464 0.73 MAOB (0.65) NISCHMAOAMAOBADRA2AKCNH2
SCHEMBL11556207 0.71 NISCH (0.55) NISCHMAOAMAOBADRA2ACACNA1F
SCHEMBL8612775 0.70 MAOB (0.53) NISCHMAOAMAOBADRA2AKCNH2
SCHEMBL8612773 0.70 MAOB (0.53) NISCHMAOAMAOBADRA2AKCNH2
Biphenyl SCHEMBL27968805 0.69 NISCH (0.58) NISCHMAOAMAOBADRA2ACACNA1F
SCHEMBL21327042 0.67 MAOB (0.50) NISCHMAOAMAOBADRA2AKCNH2
SCHEMBL11134109 0.67 NISCH (0.67) NISCHMAOAMAOBADRA2ACACNA1F

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016105449-A1 COMPOUNDS FOR USE AS PAIN THERAPEUTICS LEDERMAN SETH (US) 2016-06-30 WO disclosed