Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.42 |
| ▸ | FASN | P49327 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18880078 | 0.91 | SMYD3 (0.47) | SMYD3FASNKMT2AKDM1AL3MBTL1 | |
| SCHEMBL103477 | 0.91 | — | — | |
| SCHEMBL15480842 | 0.84 | SMYD3 (0.43) | SMYD3FASNKMT2AKDM1AL3MBTL1 | |
| SCHEMBL12385840 | 0.83 | EPHX1 (0.53) | SMYD3KMT2AKDM4EMEN1LMNA | |
| SCHEMBL12545637 | 0.83 | EPHX1 (0.53) | SMYD3KMT2AKDM4EMEN1LMNA | |
| SCHEMBL618398 | 0.83 | EPHX2 (0.58) | SMYD3FASNKMT2AKDM1AATM | |
| SCHEMBL12304480 | 0.83 | EPHX2 (0.58) | SMYD3FASNKMT2AKDM1AATM | |
| SCHEMBL18880058 | 0.83 | ATM (0.44) | SMYD3FASNKMT2AKDM1AKDM4E | |
| SCHEMBL15199116 | 0.83 | EPHX1 (0.53) | SMYD3KMT2AKDM4EMEN1LMNA | |
| SCHEMBL13457845 | 0.83 | EPHX2 (0.58) | SMYD3FASNKMT2AKDM1AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3027604-B1 | NOVEL QUINAZOLINONES AS BROMODOMAIN INHIBITORS | ZENITH EPIGENETICS LTD (CA) | 2019-02-20 | — | — | EP | disclosed |
| US-20180092924-A1 | NOVEL QUINAZOLINONES AS BROMODOMAIN INHIBITORS | RVX THERAPEUTICS INC. (CA) | 2018-04-05 | — | — | US | disclosed |
| US-9855271-B2 | Quinazolinones as bromodomain inhibitors | ZENITH EPIGENETICS LTD. (CA) | 2018-01-02 | — | — | US | disclosed |
| US-20160193218-A1 | NOVEL QUINAZOLINONES AS BROMODOMAIN INHIBITORS | ZENITH EPIGENETICS LTD. (CA) | 2016-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180092924-A1 | NOVEL QUINAZOLINONES AS BROMODOMAIN INHIBITORS | BRD4, BRD3, BRDT | SMYD3 921/4885FASN 3659/4885KMT2A 825/4885 |
| US-20160193218-A1 | NOVEL QUINAZOLINONES AS BROMODOMAIN INHIBITORS | BRD4, BRD3, BRDT | SMYD3 921/4885FASN 3659/4885KMT2A 825/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.