Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.40 |
| ▸ | KCNN4 | O15554 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8783850 | 0.86 | HIF1A (0.53) | CYP1A2KMT2AMEN1CYP2D6MAPT | |
| SCHEMBL372277 | 0.86 | HIF1A (0.53) | CYP1A2KMT2AMEN1CYP2D6MAPT | |
| SCHEMBL27979602 | 0.81 | MAPT (0.48) | CYP1A2KMT2ACYP2D6MAPTHIF1A | |
| SCHEMBL1712450 | 0.79 | CYP1A2 (0.47) | CYP1A2KMT2AMEN1CYP2D6MAPT | |
| SCHEMBL1081535 | 0.79 | CYP1A2 (0.47) | CYP1A2KMT2AMEN1CYP2D6MAPT | |
| SCHEMBL1712531 | 0.79 | CYP1A2 (0.47) | CYP1A2KMT2AMEN1CYP2D6MAPT | |
| SCHEMBL1712451 | 0.79 | CYP1A2 (0.47) | CYP1A2KMT2AMEN1CYP2D6MAPT | |
| SCHEMBL10883865 | 0.78 | CYP2C19 (0.46) | CYP1A2KMT2ACYP2D6MAPTHIF1A | |
| SCHEMBL2089245 | 0.78 | CYP1A2 (0.70) | CYP1A2KMT2AMEN1CYP2D6MAPT | |
| SCHEMBL7617984 | 0.78 | CYP1A2 (0.48) | CYP1A2KMT2AMEN1CYP2D6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016109501-A1 | AMIDE COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS | KAROS PHARMACEUTICALS, INC. (US) | 2016-07-07 | — | — | WO | disclosed |