Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | NEK1 | Q96PY6 | 2/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17892193 | 1.00 | HTR2A (0.44) | HTR2AMEN1KMT2AMITFRPS6KB1 | |
| SCHEMBL17892060 | 0.98 | HTR2A (0.43) | HTR2AMEN1KMT2AMITFRPS6KB1 | |
| SCHEMBL7237143 | 0.98 | HTR2A (0.43) | HTR2AMEN1KMT2AMITFRPS6KB1 | |
| SCHEMBL17892140 | 0.98 | HTR2A (0.43) | HTR2AMEN1KMT2AMITFRPS6KB1 | |
| SCHEMBL17892061 | 0.98 | HTR2A (0.43) | HTR2AMEN1KMT2AMITFRPS6KB1 | |
| SCHEMBL17892053 | 0.96 | HTR2A (0.44) | HTR2AMEN1KMT2AMITFRPS6KB1 | |
| SCHEMBL17892052 | 0.96 | HTR2A (0.44) | HTR2AMEN1KMT2AMITFRPS6KB1 | |
| SCHEMBL17892086 | 0.92 | HTR2A (0.47) | HTR2AMEN1KMT2AMITFRPS6KB1 | |
| SCHEMBL17892084 | 0.92 | HTR2A (0.47) | HTR2AMEN1KMT2AMITFRPS6KB1 | |
| SCHEMBL17892063 | 0.84 | HTR2A (0.38) | HTR2AMEN1KMT2AMITFRPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016109501-A1 | AMIDE COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS | KAROS PHARMACEUTICALS, INC. (US) | 2016-07-07 | — | — | WO | disclosed |
| WO-2016109501-A1 | AMIDE COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS | KAROS PHARMACEUTICALS, INC. (US) | 2016-07-07 | — | — | WO | disclosed |