Sugi Predict

Sugi Predict / Compounds / SCHEMBL1789515

SCHEMBL1789515

SCHEMBL1789515

CN(C)C1Cc2ccc(Nc3nccc(-c4c(-c5cccc(NC(=O)c6c(F)cccc6F)c5)nc5ccccn45)n3)cc2C1

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ BRAF P15056 4/20 0.74
▸ IGF1R P08069 15/20 0.67
▸ EGFR P00533 6/20 0.58
▸ ERBB2 P04626 6/20 0.58
▸ INSR P06213 2/20 0.57
▸ AURKA O14965 2/20 0.53
▸ KDR P35968 2/20 0.53
▸ AURKB Q96GD4 2/20 0.53
▸ CDK19 Q9BWU1 2/20 0.53
▸ PLK4 O00444 1/20 0.52
▸ CHEK1 O14757 1/20 0.52
▸ DAPK3 O43293 1/20 0.52
▸ ROCK2 O75116 1/20 0.52
▸ PRKD3 O94806 1/20 0.52
▸ MAP4K4 O95819 1/20 0.52
▸ PAK4 O96013 1/20 0.52
▸ CHEK2 O96017 1/20 0.52
▸ NTRK1 P04629 1/20 0.52
▸ PRKCG P05129 1/20 0.52
▸ LCK P06239 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1787212 0.93 BRAF (0.65) BRAFIGF1REGFRERBB2INSR
SCHEMBL1790531 0.91 BRAF (0.62) BRAFIGF1REGFRERBB2INSR
SCHEMBL1790262 0.89 BRAF (0.59) BRAFIGF1REGFRERBB2INSR
SCHEMBL1787851 0.89 BRAF (0.59) BRAFIGF1REGFRERBB2INSR
SCHEMBL1787183 0.88 BRAF (0.58) BRAFIGF1REGFRERBB2INSR
SCHEMBL1787812 0.88 BRAF (0.58) BRAFIGF1REGFRERBB2INSR
SCHEMBL1787770 0.88 BRAF (0.58) BRAFIGF1REGFRERBB2INSR
SCHEMBL1788279 0.87 BRAF (0.57) BRAFIGF1REGFRERBB2INSR
SCHEMBL1789384 0.87 BRAF (0.69) BRAFIGF1REGFRERBB2INSR
SCHEMBL1787695 0.87 IGF1R (0.60) BRAFIGF1REGFRERBB2INSR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9051315-B2 Imidazopyridines as a novel scaffold for multi-targeted kinase inhibition ABBVIE INC. (US) 2015-06-09 — — US claimed
EP-2496574-A1 IMIDAZOPYRIDINES AS A NOVEL SCAFFOLD FOR MULTI-TARGETED KINASE INHIBITION Abbott Laboratories (US) 2012-09-12 — — EP claimed
US-20110124632-A1 IMIDAZOPYRIDINES AS A NOVEL SCAFFOLD FOR MULTI-TARGETED KINASE INHIBITION ABBOTT LABORATORIES (US) 2011-05-26 — — US claimed
WO-2011053476-A1 IMIDAZOPYRIDINES AS A NOVEL SCAFFOLD FOR MULTI-TARGETED KINASE INHIBITION ABBOTT LABORATORIES (US) 2011-05-05 — — WO claimed
US-9051315-B2 Imidazopyridines as a novel scaffold for multi-targeted kinase inhibition ABBVIE INC. (US) 2015-06-09 — — US disclosed
EP-2496574-A1 IMIDAZOPYRIDINES AS A NOVEL SCAFFOLD FOR MULTI-TARGETED KINASE INHIBITION Abbott Laboratories (US) 2012-09-12 — — EP disclosed
US-20110124632-A1 IMIDAZOPYRIDINES AS A NOVEL SCAFFOLD FOR MULTI-TARGETED KINASE INHIBITION ABBOTT LABORATORIES (US) 2011-05-26 — — US disclosed
WO-2011053476-A1 IMIDAZOPYRIDINES AS A NOVEL SCAFFOLD FOR MULTI-TARGETED KINASE INHIBITION ABBOTT LABORATORIES (US) 2011-05-05 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110124632-A1 IMIDAZOPYRIDINES AS A NOVEL SCAFFOLD FOR MULTI-TARGETED KINASE INHIBITION PACSIN2, MAP4K2, MAP3K6 BRAF 226/4885IGF1R 937/4885EGFR 1013/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.