Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 10/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 2/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.32 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.32 |
| ▸ | ACP1 | P24666 | 1/20 | 0.31 |
| ▸ | RPLP1 | P05386 | 1/20 | 0.31 |
| ▸ | RPLP0 | P05388 | 1/20 | 0.31 |
| ▸ | RPS17 | P08708 | 1/20 | 0.31 |
| ▸ | RPSA | P08865 | 1/20 | 0.31 |
| ▸ | RPS2 | P15880 | 1/20 | 0.31 |
| ▸ | RPL35A | P18077 | 1/20 | 0.31 |
| ▸ | RPL7 | P18124 | 1/20 | 0.31 |
| ▸ | RPL17 | P18621 | 1/20 | 0.31 |
| ▸ | RPS4Y1 | P22090 | 1/20 | 0.31 |
| ▸ | RPS3 | P23396 | 1/20 | 0.31 |
| ▸ | RPS12 | P25398 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17898267 | 0.90 | KDM4C (0.43) | KDM4CPDE3BPDE3A | |
| SCHEMBL17901756 | 0.88 | ROCK1 (0.34) | KDM4CROCK1CDK4PRKCZPRKD2 | |
| SCHEMBL17898260 | 0.86 | KDM4C (0.50) | KDM4CROCK1 | |
| SCHEMBL17898279 | 0.85 | KDM4C (0.39) | KDM4CKCNH2 | |
| SCHEMBL17898277 | 0.84 | KDM4C (0.43) | KDM4C | |
| SCHEMBL17898297 | 0.84 | KDM4C (0.39) | KDM4CPRKCZ | |
| SCHEMBL17898290 | 0.82 | KDM4C (0.40) | KDM4C | |
| SCHEMBL17898287 | 0.82 | KDM4C (0.43) | KDM4C | |
| SCHEMBL17898261 | 0.81 | KDM4C (0.51) | KDM4C | |
| SCHEMBL17898291 | 0.79 | KDM4C (0.41) | KDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3430008-B1 | HISTONE DEMETHYLASE INHIBITORS | CELGENE QUANTICEL RES INC (US) | 2022-05-18 | — | — | EP | disclosed |
| US-10208039-B2 | Histone demethylase inhibitors | CELGENE QUANTICEL RESEARCH, INC. (US) | 2019-02-19 | — | — | US | disclosed |
| US-10202381-B2 | Histone demethylase inhibitors | CELGENE QUANTICEL RESEARCH, INC. (US) | 2019-02-12 | — | — | US | disclosed |
| US-10030017-B2 | Histone demethylase inhibitors | CELGENE QUANTICEL RESEARCH, INC. (US) | 2018-07-24 | — | — | US | disclosed |
| US-10030017-B2 | Histone demethylase inhibitors | CELGENE QUANTICEL RESEARCH, INC. (US) | 2018-07-24 | — | — | US | disclosed |
| US-20180162857-A1 | HISTONE DEMETHYLASE INHIBITORS | CELGENE QUANTICEL RESEARCH, INC. (US) | 2018-06-14 | — | — | US | disclosed |
| US-20180162857-A1 | HISTONE DEMETHYLASE INHIBITORS | CELGENE QUANTICEL RESEARCH, INC. (US) | 2018-06-14 | — | — | US | disclosed |
| WO-2017161012-A1 | HISTONE DEMETHYLASE INHIBITORS | CELGENE QUANTICEL RESEARCH, INC. (US) | 2017-09-21 | — | — | WO | disclosed |
| US-20160194323-A1 | HISTONE DEMETHYLASE INHIBITORS | CELGENE QUANTICEL RESEARCH, INC. | 2016-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160194323-A1 | HISTONE DEMETHYLASE INHIBITORS | KDM1B, KDM5C, KDM1A | KDM4C 9/4885ROCK1 653/4885CDK4 467/4885 |
| US-10030017-B2 | Histone demethylase inhibitors | KDM1B, KDM5C, KDM1A | KDM4C 9/4885ROCK1 653/4885CDK4 467/4885 |
| US-20180162857-A1 | HISTONE DEMETHYLASE INHIBITORS | KDM1B, KDM5C, KDM1A | KDM4C 9/4885ROCK1 653/4885CDK4 467/4885 |
| US-10202381-B2 | Histone demethylase inhibitors | KDM1B, KDM5C, KDM1A | KDM4C 9/4885ROCK1 653/4885CDK4 467/4885 |
| US-10208039-B2 | Histone demethylase inhibitors | KDM1B, KDM5C, KDM1A | KDM4C 9/4885ROCK1 653/4885CDK4 467/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.