Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.69 |
| ▸ | XDH | P47989 | 1/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.67 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.67 |
| ▸ | F3 | P13726 | 2/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.61 |
| ▸ | XBP1 | P17861 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | EP300 | Q09472 | 1/20 | 0.60 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.59 |
| ▸ | MGAM | O43451 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | SI | P14410 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30969583 | 1.00 | EGFR (0.69) | EGFRXDHCYP1A2HSD11B1F3 | |
| SCHEMBL1524863 | 0.86 | AKR1C3 (0.68) | EGFRXDHCYP1A2HSD11B1F3 | |
| SCHEMBL809546 | 0.86 | AKR1C3 (0.68) | EGFRXDHCYP1A2HSD11B1F3 | |
| SCHEMBL625119 | 0.86 | AKR1C3 (0.68) | EGFRXDHCYP1A2HSD11B1F3 | |
| SCHEMBL17077426 | 0.83 | EGFR (1.00) | EGFRXDHCYP1A2 | |
| SCHEMBL17077424 | 0.83 | EGFR (1.00) | EGFRXDHCYP1A2 | |
| SCHEMBL17899555 | 0.82 | APP (0.58) | EGFRXDHCYP1A2HSD11B1F3 | |
| SCHEMBL21612525 | 0.82 | AKR1C3 (0.62) | EGFRXDHCYP1A2HSD11B1F3 | |
| SCHEMBL624537 | 0.82 | AKR1C3 (0.62) | EGFRXDHCYP1A2HSD11B1F3 | |
| SCHEMBL3438398 | 0.82 | AKR1C3 (0.62) | EGFRXDHCYP1A2HSD11B1F3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230357200-A1 | SMALL MOLECULE STIMULATORS OF STEROID RECEPTOR COACTIVATOR-3 AND METHODS OF THEIR USE AS CARDIOPROTECTIVE AND/OR VASCULAR REGENERATIVE AGENTS | BAYLOR COLLEGE OF MEDICINE (US) | 2023-11-09 | — | — | US | disclosed |
| US-20230357200-A1 | SMALL MOLECULE STIMULATORS OF STEROID RECEPTOR COACTIVATOR-3 AND METHODS OF THEIR USE AS CARDIOPROTECTIVE AND/OR VASCULAR REGENERATIVE AGENTS | BAYLOR COLLEGE OF MEDICINE (US) | 2023-11-09 | — | — | US | disclosed |
| US-11708350-B2 | Small molecule stimulators of steroid receptor coactivator-3 and methods of their use as cardioprotective and/or vascular regenerative agents | BAYLOR COLLEGE OF MEDICINE (US) | 2023-07-25 | — | — | US | disclosed |
| US-11708350-B2 | Small molecule stimulators of steroid receptor coactivator-3 and methods of their use as cardioprotective and/or vascular regenerative agents | BAYLOR COLLEGE OF MEDICINE (US) | 2023-07-25 | — | — | US | disclosed |
| WO-2016109470-A1 | SMALL MOLECULE STIMULATORS OF STEROID RECEPTOR COACTIVATOR PROTEINS AND THEIR USE IN THE TREATMENT OF CANCER | BAYLOR COLLEGE OF MEDICINE (US) | 2016-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11708350-B2 | Small molecule stimulators of steroid receptor coactivator-3 and methods of their use as cardioprotective and/or vascular regenerative agents | NCOA3, FABP3, NCOA1 | EGFR 2269/4885XDH 3663/4885CYP1A2 4522/4885 |
| US-20230357200-A1 | SMALL MOLECULE STIMULATORS OF STEROID RECEPTOR COACTIVATOR-3 AND METHODS OF THEIR USE AS CARDIOPROTECTIVE AND/OR VASCULAR REGENERATIVE AGENTS | NCOA3, FABP3, NCOA1 | EGFR 2269/4885XDH 3663/4885CYP1A2 4522/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.