SCHEMBL17906270

SCHEMBL17906270

COc1ccc(-c2sc(NC(=O)CCC3CCCC3)nc2C)cc1S(=O)(=O)N[C@H]1CCC[C@@H](O)C1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ PI4KB Q9UBF8 18/20 1.00
▸ PIK3C2G O75747 2/20 0.79

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19303681 1.00 PI4KB (1.00) PI4KBPIK3C2G
SCHEMBL17889623 1.00 PI4KB (1.00) PI4KBPIK3C2G
SCHEMBL17889617 0.93 PI4KB (1.00) PI4KBPIK3C2G
SCHEMBL31323365 0.93 PI4KB (1.00) PI4KBPIK3C2G
SCHEMBL17906232 0.93 PI4KB (1.00) PI4KBPIK3C2G
SCHEMBL19997311 0.92 PI4KB (0.85) PI4KBPIK3C2G
SCHEMBL17906272 0.92 PI4KB (0.85) PI4KBPIK3C2G
SCHEMBL17904381 0.91 PI4KB (0.83) PI4KBPIK3C2G
SCHEMBL17889536 0.88 PI4KB (1.00) PI4KBPIK3C2G
SCHEMBL17889641 0.88 PIK3C2G (1.00) PI4KBPIK3C2G

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3419980-B1 PI-KINASE INHIBITORS WITH ANTI-INFECTIVE ACTIVITY UNIV LELAND STANFORD JUNIOR (US) 2025-01-01 — — EP disclosed
US-20220017507-A1 PI-Kinase Inhibitors with Anti-Infective Activity THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2022-01-20 — — US disclosed
US-11091472-B2 PI-kinase inhibitors with anti-infective activity THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2021-08-17 — — US disclosed
US-10428060-B2 PI-kinase inhibitors with anti-infective activity THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2019-10-01 — — US disclosed
US-10428060-B2 PI-kinase inhibitors with anti-infective activity THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2019-10-01 — — US disclosed
US-20180170924-A1 PI-KINASE INHIBITORS WITH ANTI-INFECTIVE ACTIVITY THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY 2018-06-21 — — US disclosed
US-20180170924-A1 PI-KINASE INHIBITORS WITH ANTI-INFECTIVE ACTIVITY THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY 2018-06-21 — — US disclosed
US-9926309-B2 Pi-kinase inhibitors with anti-infective activity THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2018-03-27 — — US disclosed
WO-2017147526-A1 PI-KINASE INHIBITORS WITH ANTI-INFECTIVE ACTIVITY THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2017-08-31 — — WO disclosed
US-20160194314-A1 PI-KINASE INHIBITORS WITH ANTI-INFECTIVE ACTIVITY NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2016-07-07 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11091472-B2 PI-kinase inhibitors with anti-infective activity PIP4K2A, PIP5K1A, PIP4K2C PI4KB 9/4885PIK3C2G 100/4885
US-20220017507-A1 PI-Kinase Inhibitors with Anti-Infective Activity PIP4K2A, PIP5K1A, PIP4K2C PI4KB 9/4885PIK3C2G 98/4885
US-20180170924-A1 PI-KINASE INHIBITORS WITH ANTI-INFECTIVE ACTIVITY PIP4K2A, PIP5K1A, PIP4K2C PI4KB 9/4885PIK3C2G 100/4885
US-20160194314-A1 PI-KINASE INHIBITORS WITH ANTI-INFECTIVE ACTIVITY PIP4K2A, PIP5K1A, PIP4K2C PI4KB 9/4885PIK3C2G 100/4885
US-10428060-B2 PI-kinase inhibitors with anti-infective activity PIP4K2A, PIP5K1A, PIP4K2C PI4KB 9/4885PIK3C2G 100/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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