Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 17/20 | 0.61 |
| ▸ | PDE6C | P51160 | 1/20 | 0.46 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.42 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2579639 | 0.84 | PDE5A (0.84) | PDE5APDE6CPDE11A | |
| SCHEMBL2565444 | 0.71 | PDE5A (0.73) | PDE5APDE6CPDE11A | |
| SCHEMBL17906564 | 0.70 | PDE5A (0.72) | PDE5APDE6CPDE11A | |
| SCHEMBL16199262 | 0.70 | PDE5A (0.73) | PDE5APDE6CPDE11A | |
| SCHEMBL17888956 | 0.70 | PDE5A (0.78) | PDE5APDE6CPDE11A | |
| SCHEMBL2567295 | 0.70 | PDE5A (0.77) | PDE5APDE6CPDE11A | |
| SCHEMBL2562779 | 0.69 | PDE5A (0.71) | PDE5APDE6CPDE11A | |
| SCHEMBL16188275 | 0.69 | PDE5A (0.69) | PDE5APDE6CPDE11A | |
| SCHEMBL2567665 | 0.69 | PDE5A (0.71) | PDE5APDE6CPDE11A | |
| SCHEMBL16199266 | 0.69 | PDE5A (1.00) | PDE5APDE6CPDE11A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2383262-B1 | PHENYL PYRIMIDONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, PREPARATION METHODS AND USES THEREOF | TOPHARMAN SHANGHAI CO LTD (CN) | 2016-07-06 | — | — | EP | disclosed |