Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | PRKACA | P17612 | 2/20 | 0.44 |
| ▸ | JAK3 | P52333 | 2/20 | 0.44 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | PAK4 | O96013 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2355622 | 0.91 | AURKB (0.52) | RAB9ANPC1HPGDSMN1; SMN2ROCK1 | |
| SCHEMBL2358817 | 0.90 | JAK2 (0.46) | ROCK1JAK2PRKACAJAK3PRKCQ | |
| SCHEMBL2356649 | 0.80 | CCNK (0.55) | RAB9AHPGDROCK1AURKBPTK2 | |
| SCHEMBL2356502 | 0.78 | ROCK1 (0.48) | RAB9ANPC1HPGDSMN1; SMN2ROCK1 | |
| SCHEMBL2357985 | 0.76 | SMN1; SMN2 (0.55) | RAB9ANPC1HPGDSMN1; SMN2ROCK1 | |
| SCHEMBL2357610 | 0.75 | IKBKB (0.49) | RAB9ANPC1SMN1; SMN2ROCK1JAK2 | |
| SCHEMBL5112553 | 0.75 | IKBKB (0.47) | ROCK1JAK2PRKACAJAK3PRKCQ | |
| Cyclopentane SCHEMBL2358084 | 0.74 | CCNK (0.48) | ROCK1JAK2PRKACAJAK3PRKCQ | |
| SCHEMBL5122070 | 0.73 | NEK1 (0.45) | ROCK1JAK2PRKACAJAK3PRKCQ | |
| SCHEMBL2356243 | 0.72 | CIT (0.47) | ROCK1JAK2PRKACAJAK3PRKCQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3042655-A1 | JANUS KINASE INHIBITORS FOR TREATMENT OF DRY EYE AND OTHER EYE RELATED DISEASES | Incyte Holdings Corporation (US) | 2016-07-13 | — | — | EP | claimed |